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Spotlight Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
- 1.0544809 - ÚMG 2022 RIV GB eng O - Others
Sohrabi, Yahya - Reinecke, H. - Godfrey, R.
Spotlight Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19.
Trends in Endocrinology and Metabolism. Elsevier. Roč. 32, č. 3 (2021), s. 132-134. ISSN 1043-2760. E-ISSN 1879-3061
Institutional support: RVO:68378050
Keywords : COVID-19 * cholesterol synthesis * cytokine storm * lipid synthesis * obesity
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Method of publishing: Open access
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(21)00001-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1043276021000011%3Fshowall%3Dtrue
Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
Permanent Link: http://hdl.handle.net/11104/0321617
Number of the records: 1