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Polarization-resolved second-harmonic generation imaging through a multimode fiber

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    0544708 - ÚPT 2022 RIV US eng J - Journal Article
    Cifuentes, Angel S. - Pikálek, Tomáš - Ondráčková, Petra - Amezcua-Correa, R. - Antonio-Lopez, J. E. - Čižmár, Tomáš - Traegaardh, Johanna
    Polarization-resolved second-harmonic generation imaging through a multimode fiber.
    Optica. Roč. 8, č. 8 (2021), s. 1065-1074. ISSN 2334-2536. E-ISSN 2334-2536
    R&D Projects: GA MŠMT EF15_003/0000476; GA MŠMT ED0017/01/01; GA MŠMT(CZ) LO1212
    Institutional support: RVO:68081731
    Keywords : second harmonic generation * multimode fiber * bioimaging * polarization control
    OECD category: Optics (including laser optics and quantum optics)
    Impact factor: 10.644, year: 2021
    Method of publishing: Open access
    https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-8-8-1065&id=453930

    Multimode fiber-based endoscopes have recently emerged as a tool for minimally invasive endoscopy in tissue, at depths well beyond the reach of multiphoton imaging. Here, we demonstrate label-free second-harmonic generation (SHG) microscopy through such a fiber endoscope. We simultaneously fully control the excitation polarization state and the spatial distribution of the light at the fiber tip, and we use this to implement polarization-resolved SHG imaging, which allows imaging and identification of structural proteins such as collagen and myosin.We image mouse tail tendon and heart tissue, employing the endoscope at depths up to 1 mm, demonstrating that we can differentiate these structural proteins. This method has the potential for enabling instant and in situ diagnosis of tumors and fibrotic conditions insensitive tissue with minimal damage.
    Permanent Link: http://hdl.handle.net/11104/0321538


    Research data: Figshare
     
     
Number of the records: 1  

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