0544568 - FGÚ 2022 RIV IE eng J - Journal Article
Valeš, Karel - Holubová, K.
Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions.
Neuroscience Letters. Roč. 761, Sep 14 (2021), č. článku 136098. ISSN 0304-3940. E-ISSN 1872-7972
R&D Projects: GA MZd(CZ) EF16_025/0007444; GA ČR(CZ) GA18-09296S
Institutional support: RVO:67985823
Keywords : schizophrenia * antipsychotics * cognition * Morris water maze * pre-pulse inhibition * MK-801
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.197, year: 2021 ; AIS: 0.62, rok: 2021
Method of publishing: Limited access
Result website:
https://doi.org/10.1016/j.neulet.2021.136098DOI: https://doi.org/10.1016/j.neulet.2021.136098

Schizophrenia is a debilitating mental disorder characterized by positive, negative and cognitive symptoms. Whereas positive symptoms are satisfactorily addressed by current antipsychotic treatment, negative and cognitive symptomatic treatment remains largely ineffective. This review investigates the treatment efficacy regarding cognitive symptoms and evaluates the contribution of different monoamine receptor systems involved in schizophrenia pathophysiology to cognition. In the review, we included preclinical studies assessing the effect of different treatments on cognition in pre-pulse inhibition and two spatial cognitive tests. While pre-pulse inhibition investigates pre-attentive processes operating outside of conscious awareness, the spatial tasks require continuous attention and active engagement in task solving for a successful outcome. The schizophrenia-like phenotype was attained by acute or subchronic administration of non-competitive NMDA receptor antagonist MK-801.
Permanent Link: http://hdl.handle.net/11104/0321416