Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles

0544174 - ÚMCH 2022 RIV CH eng J - Journal Article
Gorshkova, Y. - Barbinta-Patrascu, M.-E. - Bokuchava, G. - Badea, N. - Ungureanu, C. - Lazea-Stoyanova, A. - Raileanu, M. - Bacalum, M. - Turchenko, V. - Zhigunov, Alexander - Juszyńska-Galazka, E.
Biological performances of plasmonic biohybrids based on phyto-silver/silver chloride nanoparticles.
Nanomaterials. Roč. 11, č. 7 (2021), č. článku 1811. E-ISSN 2079-4991
Grant - others:Committee for collaboration of Czech Republic with Joint Institute for Nuclear Research in Dubna(RU) 04-4-1121
Institutional support: RVO:61389013
Keywords : silver/silver chloride nanoparticles * “green” synthesis * chlorophyll-a-labeled bio-inspired membranes
OECD category: Polymer science
Impact factor: 5.719, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2079-4991/11/7/1811

Silver/silver chloride nanoparticles (Ag/AgClNPs), with a mean size of 48.2 ± 9.5 nm and a zeta potential value of −31.1 ± 1.9 mV, obtained by the Green Chemistry approach from a mixture of nettle and grape extracts, were used as “building blocks” for the “green” development of plasmonic biohybrids containing biomimetic membranes and chitosan. The mechanism of biohybrid formation was elucidated by optical analyses (UV–vis absorption and emission fluorescence, FTIR, XRD, and SAXS) and microscopic techniques (AFM and SEM). The aforementioned novel materials showed a free radical scavenging capacity of 75% and excellent antimicrobial properties against Escherichia coli (IGZ = 45 mm) and Staphylococcus aureus (IGZ = 35 mm). The antiproliferative activity of biohybrids was highlighted by a therapeutic index value of 1.30 for HT-29 cancer cells and 1.77 for HepG2 cancer cells. At concentrations below 102.2 µM, these materials are not hemolytic, so they will not be harmful when found in the bloodstream. In conclusion, hybrid systems based on phyto-Ag/AgClNPs, artificial cell membranes, and chitosan can be considered potential adjuvants in liver and colorectal cancer treatment.
Permanent Link: http://hdl.handle.net/11104/0321225