Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1

0544140 - ÚMG 2022 RIV CH eng J - Journal Article
Fabišik, Matěj - Turečková, Jolana - Pavliuchenko, Nataliia - Králová, Jarmila - Balounová, Jana - Vičíková, Kristína - Skopcová, Tereza - Špoutil, František - Pokorná, Jana - Angelisová, Pavla - Malissen, B. - Procházka, Jan - Sedláček, Radislav - Brdička, Tomáš
Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.
Frontiers in Immunology. Roč. 12, April (2021), č. článku 618332. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA ČR(CZ) GBP302/12/G101; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT EF16_013/0001789
Institutional support: RVO:68378050
Keywords : lst1 * inflammation * colitis * inflammatory bowel disease * myeloid cells
OECD category: Immunology
Impact factor: 8.787, year: 2021
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2021.618332/full

LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved in cytoskeleton regulation and generation of tunneling nanotubes. LST1 gene is located in MHCIII locus close to many immunologically relevant genes. In addition, its expression increases under inflammatory conditions such as viral infection, rheumatoid arthritis and inflammatory bowel disease and its deficiency was shown to result in slightly increased sensitivity to influenza infection in mice. However, little else is known about its role in the immune system homeostasis and immune response. Here we show that similar to humans, LST1 is expressed in mice in the cells of the myeloid lineage. In vivo, its deficiency results in alterations in multiple leukocyte subset abundance in steady state and under inflammatory conditions. Moreover, LST1-deficient mice show significant level of resistance to dextran sodium sulphate (DSS) induced acute colitis, a model of inflammatory bowel disease. These data demonstrate that LST1 regulates leukocyte abundance in lymphoid organs and inflammatory response in the gut.
Permanent Link: http://hdl.handle.net/11104/0321183