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Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms

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    0543461 - ÚOCHB 2022 RIV US eng J - Journal Article
    Lemberg, M. K. - Stříšovský, Kvido
    Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms.
    Molecular Cell. Roč. 81, č. 12 (2021), s. 2507-2519. ISSN 1097-2765. E-ISSN 1097-4164
    R&D Projects: GA ČR(CZ) GA18-09556S; GA ČR(CZ) GA20-25331S; GA MŠk(CZ) EF16_019/0000729
    Institutional support: RVO:61388963
    Keywords : reticulum-associated degradation * signal peptide peptidase * class I molecules
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 17.970, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1016/j.molcel.2021.05.004

    Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degraded in the cytoplasm. The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway is the best-understood organellar protein quality control system. Here, we review new insights into the mechanism of recognition and retrotranslocation of client proteins in ERAD. In addition to the membrane-integral ERAD E3 ubiquitin ligases, we highlight one protein family that is remarkably often involved in various aspects of membrane protein quality control and protein dislocation: the rhomboid superfamily, which includes derlins and intramembrane serine proteases. Rhomboid-like proteins have been found to control protein homeostasis in the ER, but also in other eukaryotic organelles and in bacteria, pointing toward conserved principles of membrane protein quality control across organelles and evolution.
    Permanent Link: http://hdl.handle.net/11104/0320659

     
     
Number of the records: 1