0543461 - ÚOCHB 2022 RIV US eng J - Journal Article
Lemberg, M. K. - Stříšovský, Kvido
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms.
Molecular Cell. Roč. 81, č. 12 (2021), s. 2507-2519. ISSN 1097-2765. E-ISSN 1097-4164
R&D Projects: GA ČR(CZ) GA18-09556S; GA ČR(CZ) GA20-25331S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : reticulum-associated degradation * signal peptide peptidase * class I molecules
OECD category: Biochemistry and molecular biology
Impact factor: 19.328, year: 2021
Method of publishing: Limited access
Result website:
https://doi.org/10.1016/j.molcel.2021.05.004
DOI: https://doi.org/10.1016/j.molcel.2021.05.004

Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degraded in the cytoplasm. The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway is the best-understood organellar protein quality control system. Here, we review new insights into the mechanism of recognition and retrotranslocation of client proteins in ERAD. In addition to the membrane-integral ERAD E3 ubiquitin ligases, we highlight one protein family that is remarkably often involved in various aspects of membrane protein quality control and protein dislocation: the rhomboid superfamily, which includes derlins and intramembrane serine proteases. Rhomboid-like proteins have been found to control protein homeostasis in the ER, but also in other eukaryotic organelles and in bacteria, pointing toward conserved principles of membrane protein quality control across organelles and evolution.

Permanent Link: http://hdl.handle.net/11104/0320659