Number of the records: 1  

Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides

  1. 1.
    0543389 - ÚOCHB 2022 RIV GB eng J - Journal Article
    Lášek, Tomáš - Dobiaš, Juraj - Buděšínský, Miloš - Kozák, Jaroslav - Lapuníková, Barbora - Rosenberg, Ivan - Birkuš, Gabriel - Páv, Ondřej
    Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose D-nucleosides and tetradialdose D-nucleosides.
    Tetrahedron. Roč. 89, Jun 4 (2021), č. článku 132159. ISSN 0040-4020. E-ISSN 1464-5416
    R&D Projects: GA MŠk(CZ) EF16_019/0000729
    Institutional support: RVO:61388963
    Keywords : nucleoside phosphonate * triphosphate * prodrug * tetradialdose d-nucleoside * 2′-fluoronucleoside
    OBOR OECD: Organic chemistry
    Impact factor: 2.457, year: 2020
    https://doi.org/10.1016/j.tet.2021.132159

    Analogs of nucleosides and nucleotides represent a promising pool of potential therapeutics. This work describes a new synthetic route leading to 2′-deoxy-2′-fluorotetradialdose D-nucleoside phosphonates. Moreover, a new universal synthetic route leading to tetradialdose d-nucleosides bearing purine nucleobases is also described. All new compounds were tested as triphosphate analogs for inhibitory potency against a variety of viral polymerases. The fluorinated nucleosides were transformed to phosphoramidate prodrugs and evaluated in cell cultures against various viruses including influenza and SARS-CoV-2.
    Permanent Link: http://hdl.handle.net/11104/0320603
     
     
Number of the records: 1