Sex differences in a neurodevelopmental animal model of schizophrenia: focus on white matter structures and myelin

0543012 - ÚPT 2022 NL eng A - Abstract
Štark, T. - Dražanová, Eva - Vaškovicová, Naděžda - Pekařík, V. - Rudá-Kučerová, J. - Skoupý, Radim - Kulich, P. - Buchtová, Marcela - Starčuk jr., Zenon - Drago, F. - Šulcová, A. - Micale, V.
Sex differences in a neurodevelopmental animal model of schizophrenia: focus on white matter structures and myelin.
European Neuropsychopharmacology. Elsevier. Roč. 27, Supplement 4 (2017), S890-S891. ISSN 0924-977X. E-ISSN 1873-7862.
[Congress of the European-College-of-Neuropsychopharmacology (ECNP) /30./. 02.09.2017-05.09.2017, Paris]
Institutional support: RVO:68081731 ; RVO:67985904
Keywords : schizophrenia animal model * white matter * myelin * sex differences
OECD category: 1.7 Other natural sciences; Developmental biology (UZFG-Y)
https://www.sciencedirect.com/science/article/pii/S0924977X17315900?via%3Dihub

Several clinical studies identify sex differences in the development and clinical expression of schizophrenia (SCZ), with higher incidence and early onset in men. Although white matter dysfunction and myelin impairment seem to play important role in pathophysiology of SCZ, the potential sex differences in this regard have to be elucidated. It is accepted that SCZ may originate from abnormal brain development that only becomes evident in adulthood, thus we assessed if the behavioral changes mimicking SCZ phenotype in both sexes are paralleled with alterations in white matter structures and myelin in a neurodevelopmental animal model of SCZ.
Permanent Link: http://hdl.handle.net/11104/0320326