Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice

0542832 - FGÚ 2022 RIV DE eng J - Journal Article
Benlebna, M. - Balas, L. - Bonafos, B. - Pessemesse, L. - Fouret, G. - Vigor, C. - Gaillet, S. - Grober, J. - Bernex, F. - Landrier, J.F. - Kuda, Ondřej - Durand, T. - Coudray, Ch. - Casas, F. - Feillet-Coudray, Ch.
Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice.
European Journal of Nutrition. Roč. 60, č. 4 (2021), s. 2013-2027. ISSN 1436-6207. E-ISSN 1436-6215
R&D Projects: GA ČR(CZ) GA20-00317S
Institutional support: RVO:67985823
Keywords : FAHFA * basal metabolism * insulin sensitivity * liver steatosis * mitochondria * oxidative stress mice
OECD category: Biochemistry and molecular biology
Impact factor: 4.865, year: 2021
Method of publishing: Limited access
https://doi.org/10.1007/s00394-020-02391-1

Purpose: Fatty acid esters of hydroxy fatty acids (FAHFAs) are a large family of endogenous bioactive lipids. To date, most of the studied FAHFAs are branched regioisomers of Palmitic Acid Hydroxyl Stearic Acid (PAHSA) that were reported to possess anti-diabetic and anti-inflammatory activity in humans and rodents. Recently, we have demonstrated that 9-PAHPA or 9-OAHPA intake increased basal metabolism and enhanced insulin sensitivity in healthy control diet-fed mice but induced liver damage in some mice. The present work aims to explore whether a long-term intake of 9-PAHPA or 9-OAHPA may have similar effects in obesogenic diet-fed mice. Methods:C57Bl6 mice were fed with a control or high fat-high sugar (HFHS) diets for 12 weeks. The HFHS diet was supplemented or not with 9-PAHPA or 9-OAHPA. Whole-body metabolism was explored. Glucose and lipid metabolism as well as mitochondrial activity and oxidative stress status were analyzed. Results: As expected, the intake of HFHS diet led to obesity and lower insulin sensitivity with minor effects on liver parameters. The long-term intake of 9-PAHPA or 9-OAHPA modulated favorably the basal metabolism and improved insulin sensitivity as measured by insulin tolerance test. On the contrary to what we have reported previously in healthy mice, no marked effect for these FAHFAs was observed on liver metabolism of obese diabetic mice. Conclusion : This study indicates that both 9-PAHPA and 9-OAHPA may have interesting insulin-sensitizing effects in obese mice with lower insulin sensitivity.
Permanent Link: http://hdl.handle.net/11104/0320179