0542584 - MBÚ 2022 RIV LT eng J - Journal Article
Mishra, Rajbardhan - Rajsiglová, Lenka - Lukáč, Pavol - Tenti, Paolo - Šíma, Petr - Čaja, Fabian - Vannucci, Luca
Spontaneous and Induced Tumors in Germ-Free Animals: A General Review.
Medicina-Lithuania. Roč. 57, č. 3 (2021), č. článku 260. ISSN 1010-660X. E-ISSN 1648-9144
Institutional support: RVO:61388971
Keywords : germ-free animals * microbiome * spontaneous tumors * induced tumors * colorectal cancer
OECD category: Microbiology
Impact factor: 2.948, year: 2021
Method of publishing: Open access
Result website:
https://www.mdpi.com/1648-9144/57/3/260
DOI: https://doi.org/10.3390/medicina57030260

Cancer, bacteria, and immunity relationships are much-debated topics in the last decade. Microbiome's importance for metabolic and immunologic modulation of the organism adaptation and responses has become progressively evident, and models to study these relationships, especially about carcinogenesis, have acquired primary importance. The availability of germ-free (GF) animals, i.e., animals born and maintained under completely sterile conditions avoiding the microbiome development offers a unique tool to investigate the role that bacteria can have in carcinogenesis and tumor development. The comparison between GF animals with the conventional (CV) counterpart with microbiome can help to evidence conditions and mechanisms directly involving bacterial activities in the modulation of carcinogenesis processes. Here, we review the literature about spontaneous cancer and cancer modeling in GF animals since the early studies, trying to offer a practical overview on the argument.

Permanent Link: http://hdl.handle.net/11104/0319971