Antifouling fluoropolymer-coated nanomaterials for 19F MRI

0542275 - ÚMCH 2022 RIV GB eng J - Journal Article
Jirák, D. - Svoboda, Jan - Filipová, Marcela - Pop-Georgievski, Ognen - Sedláček, O.
Antifouling fluoropolymer-coated nanomaterials for 19F MRI.
Chemical Communications. Roč. 57, č. 38 (2021), s. 4718-4721. ISSN 1359-7345. E-ISSN 1364-548X
R&D Projects: GA ČR(CZ) GA20-07313S
Institutional support: RVO:61389013
Keywords : MRI agents * 19F MRI tracing * antifouling brush
OECD category: Physical chemistry
Impact factor: 6.065, year: 2021
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC00642H#!divAbstract

We developed a multifunctional polymer coating for nanoparticles (NPs) that enables simultaneous detection by 19F MRI and shielding from blood plasma fouling. The coating is based on a water-soluble fluorinated poly(N-(2-fluoroethyl)acrylamide) (PFEAM) that shows high 19F MRI sensitivity, cytocompatibility and excellent antifouling properties, significantly outperforming polyethylene glycol. A proof-of-concept experiment was performed by synthesizing polymer-coated gold NPs that were successfully visualized by 19F MRI at magnetic fields close to the fields used in clinical practice. This universal approach can be used for coating and tracing of various NPs upon suitable polymer chain-end modification.
Permanent Link: http://hdl.handle.net/11104/0320013