Number of the records: 1
The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways
- 1.0542084 - BFÚ 2022 RIV CH eng J - Journal Article
Goffová, I. - Fajkus, Jiří
The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways.
International Journal of Molecular Sciences. Roč. 22, č. 3 (2021), č. článku 1302. E-ISSN 1422-0067
R&D Projects: GA MŠMT EF15_003/0000477
Institutional support: RVO:68081707
Keywords : rDNA organization * genome stability * rRNA genes * ribosome * caf-1 * rad51 * rtel1
OECD category: Biochemistry and molecular biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/3/1302
Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree.
Permanent Link: http://hdl.handle.net/11104/0319574
Number of the records: 1