Number of the records: 1
Control of oxidative stress in Jurkat cells as a model of leukemia treatment
- 1.0541846 - FZÚ 2022 RIV NL eng J - Journal Article
Pshenichnikov, S. - Omelyanchik, A. - Efremova, M. - Lunova, Mariia - Gazatova, N. - Malashchenko, V. - Khaziakhmatova, O. - Litvinova, L. - Perov, N. - Panina, L. - Peddis, D. - Lunov, Oleg - Rodionova, V. - Levada, K.
Control of oxidative stress in Jurkat cells as a model of leukemia treatment.
Journal of Magnetism and Magnetic Materials. Roč. 523, April (2021), č. článku 167623. ISSN 0304-8853. E-ISSN 1873-4766
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : magnetic nanoparticles * cytotoxicity * PBMC * jurkat * leukemia * magnetic fields
OECD category: Biophysics
Impact factor: 3.097, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.jmmm.2020.167623
This paper describes proof-of-concept for antileukemia treatment based on the reactive oxygen species (ROS) induction supplemented with magnetic nanoparticles in the presence of moderate-intensity magnetic fields. The T-lymphoblastic leukemia cell line (Jurkat) was chosen as an in vitro model of acute lymphoblastic leukemia. The elevated ROS levels were generated by iron oxide magnetic nanoparticles. We found an enhanced cytotoxic effect of magnetic nanoparticles in the presence of a magnetic field on cancerous Jurkat cell line due to induced oxidative stress after cultivation in magnetic fields with an average strength of 0.26–0.36 T and the field spatial gradient up to 100 T/m. At the same conditions of nanoparticles intake, the viability of human peripheral blood mononuclear cells (model of healthy cells) was not inhibited. Thus, we demonstrated the feasibility of antileukemia treatment by magnetic nanoparticles controlled by a magnetic field.
Permanent Link: http://hdl.handle.net/11104/0319357
Number of the records: 1