Early infection-induced natural antibody response

0541608 - MBÚ 2022 RIV GB eng J - Journal Article
Kubelková, K. - Hudcovic, Tomáš - Kozáková, Hana - Pejchal, J. - Macela, A.
Early infection-induced natural antibody response.
Scientific Reports. Roč. 11, č. 1 (2021), č. článku 1541. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA19-08294S
Institutional support: RVO:61388971
Keywords : live vaccine strain * bacterium francisella-tularensis * early protective immunity * intracellular bacterium * t-cells
OECD category: Infectious Diseases
Impact factor: 4.997, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41598-021-81083-0

There remains to this day a great gap in understanding as to the role of B cells and their products-antibodies and cytokines-in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens. We previously have demonstrated that Francisella interacts directly with peritoneal B-1a cells. Here, we demonstrate that, as early as 12 h postinfection, germ-free mice infected with Francisella tularensis produce infection-induced antibody clones reacting with Francisella tularensis proteins having orthologs or analogs in eukaryotic cells. Production of some individual clones was limited in time and was influenced by virulence of the Francisella strain used. The phylogenetically stabilized defense mechanism can utilize these early infection-induced antibodies both to recognize components of the invading pathogens and to eliminate molecular residues of infection-damaged self cells.
Permanent Link: http://hdl.handle.net/11104/0319141