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Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats
- 1.0541569 - FGÚ 2022 RIV NL eng J - Journal Article
Mareš, Pavel - Kubová, Hana
Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats.
Epilepsy Research. Roč. 169, Jan (2021), č. článku 106523. ISSN 0920-1211. E-ISSN 1872-6844
R&D Projects: GA MŠMT(CZ) LH15032; GA ČR(CZ) GA18-09296S; GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:67985823
Keywords : perampanel * AMPA receptors * pentylenetetrazol * rat * postnatal development
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.991, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.eplepsyres.2020.106523
Perampanel is a new antiepileptic drug with unique mechanism of action - antagonism of AMPA receptors. Its action in immature animals is not yet sufficiently known therefore we started to study anticonvulsant action of perampanel pretreatment (1-20 mg/kg i.p.) against seizures elicited by pentylenetetrazol. Three age groups of rats were examined - 12, 18 and 25 days old. Perampanel selectively suppressed the tonic phase of generalized seizures in the two younger groups and whole tonic-clonic seizures in the 25-day-old group. It exhibited also an anticonvulsant action against minimal clonic seizures present in control 18- and 25-day-old rats.
Permanent Link: http://hdl.handle.net/11104/0319108
Number of the records: 1