Number of the records: 1  

Reagent and analyte ion hydrates in secondary electrospray ionization mass spectrometry (SESI-MS), their equilibrium distributions and dehydration in an ion transfer capillary: Modelling and experiments

  1. 1.
    0541427 - ÚFCH JH 2022 RIV GB eng J - Journal Article
    Dryahina, Kseniya - Som, Suman - Smith, D. - Španěl, Patrik
    Reagent and analyte ion hydrates in secondary electrospray ionization mass spectrometry (SESI-MS), their equilibrium distributions and dehydration in an ion transfer capillary: Modelling and experiments.
    Rapid Communications in Mass Spectrometry. Roč. 35, č. 7 (2021), č. článku e9047. ISSN 0951-4198. E-ISSN 1097-0231
    R&D Projects: GA ČR(CZ) GA18-12902S
    Institutional support: RVO:61388955
    Keywords : Electronic Tongues * Volatile Organic Compounds * Acetone
    OECD category: Physical chemistry
    Impact factor: 2.586, year: 2021
    Method of publishing: Limited access

    Rationale: Secondary electrospray ionization (SESI) in a water spray environment at atmospheric pressure involves the reactions of hydrated hydronium reagent ions, H3O+(H2O)n, with trace analyte compounds in air samples. Understanding the formation and dehydration of reagent and analyte ions is the foundation for meaningful quantification of trace compounds by SESI-mass spectrometry (MS). Methods: A numerical model based on gas-phase ion thermochemistry is developed that describes equilibria in H3O+(H2O)n reagent cluster ion distributions and ligand switching reactions with polar NH3 molecules leading to equilibrated hydrated ammonium ions NH4+(H2O)m. The model predictions are compared with experimental results obtained using a cylindrical SESI source coupled to an ion-trap mass spectrometer via a heated ion transfer capillary. Non-polar isoprene, C5H8, was used to further probe the nature of the reagent ions. Results: Equilibrium distributions of H3O+(H2O)n ions and their reactions with NH3 molecules have been characterized by the model in the near-atmospheric pressure SESI source. NH3 analyte molecules displace H2O ligands from the H3O+(H2O)n ions at the collisional rate forming NH4+(H2O)m ions, which travel through the heated ion transfer capillary losing H2O molecules. The data for variable NH3 concentrations match the model predictions and the C5H8 test substantiates the notion of dehydration in the heated capillary. Conclusions: Large cluster ions formed in the SESI region are dehydrated to H3O+(H2O)1,2,3 and NH4+(H2O)1,2 while passing through the heated capillary, and considerable diffusion losses also occur. This phenomenon is also predicted for other polar analyte molecules, A, that can undergo similar switching reactions, thus forming AH+ and AH+(H2O)m analyte ions.
    Permanent Link: http://hdl.handle.net/11104/0318988

     
    FileDownloadSizeCommentaryVersionAccess
    0541427.pdf13 MBPublisher’s postprintrequire
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.