Polymer materials as promoters/inhibitors of amyloid fibril formation

0541039 - ÚMCH 2022 RIV DE eng J - Journal Article
Holubová, Monika - Štěpánek, Petr - Hrubý, Martin
Polymer materials as promoters/inhibitors of amyloid fibril formation.
Colloid and Polymer Science. Roč. 299, č. 3 (2021), s. 343-362. ISSN 0303-402X. E-ISSN 1435-1536
R&D Projects: GA ČR(CZ) GA19-01438S; GA ČR(CZ) GA18-07983S
Institutional support: RVO:61389013
Keywords : amyloidosis * amyloid fibrils * polymer
OECD category: Polymer science
Impact factor: 2.434, year: 2021
Method of publishing: Limited access
https://link.springer.com/article/10.1007%2Fs00396-020-04710-8

Polymers are omnipresent materials that are widely used in medicine, e.g., as construction materials for medical devices or as polymer nanoparticle drug delivery systems. Therefore, their possible effects on biomolecules, such as lipids, proteins, and other molecules, present in the human body must be examined. This review addresses the effects of polymer materials (such as dendrimers, polysaccharides) on the process of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues, causing their dysfunction. The treatment of amyloidoses, such as Alzheimer’s disease (AD), using polymer materials is a challenge. Studies aiming to elucidate the effects of polymers on the process of amyloid fibril formation are therefore also of key importance for understanding the process of amyloid fibril formation and amyloidoses in general.
Permanent Link: http://hdl.handle.net/11104/0319046