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Optical sensors of heterotrimeric G protein signaling
- 1.0540889 - ÚOCHB 2022 RIV GB eng J - Journal Article
Bondar, Alexey - Lazar, Josef
Optical sensors of heterotrimeric G protein signaling.
FEBS Journal. Roč. 288, č. 8 (2021), s. 2570-2584. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LTAIN19167
Institutional support: RVO:61388963
Keywords : BRET * FRET * G protein * G protein-coupled receptor * imaging * optogenetics * polarization microscopy * sensor * single‐molecule imaging * TIRF
OECD category: Physical chemistry
Impact factor: 5.622, year: 2021
Method of publishing: Limited access
https://doi.org/10.1111/febs.15655
Heterotrimeric G proteins are central mediators of cellular signal transduction. They receive, process, and transduce signals from G protein‐coupled receptors to downstream effectors. Since their discovery, a number of optical sensors of G protein localisation and function have been developed and applied in living systems. In this minireview, we provide an overview of existing G protein‐based sensors and the experimental approaches they utilise, with emphasis on live‐cell imaging techniques. We outline recent advances, as well as identify current challenges and likely future directions in the field of G protein sensor development.
Permanent Link: http://hdl.handle.net/11104/0318492
Number of the records: 1