Pattern recognition receptors in annelids

0540856 - MBÚ 2021 RIV GB eng J - Journal Article
Procházková, Petra - Roubalová, Radka - Dvořák, Jiří - Navarro Pacheco, Natividad Isabel - Bilej, Martin
Pattern recognition receptors in annelids.
Developmental and Comparative Immunology. Roč. 102, JAN 2020 (2020), č. článku UNSP 103493. ISSN 0145-305X. E-ISSN 1879-0089
EU Projects: European Commission(XE) 671881 - PANDORA
Institutional support: RVO:61388971
Keywords : Earthworm * Annelida * Phenoloxidase cascade
OECD category: Immunology
Impact factor: 3.636, year: 2020
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0145305X1930312X?via%3Dihub

The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of various proinflammatory molecules. These recognition molecules represent an important and efficient innate immunity tool of all organisms. As invertebrates lack the instruments of the adaptive immune system, based on
´true´ lymphocytes and functional antibodies, the importance of PRRs are even more fundamental. In the present review, the structure, specificity, and expression profiles of PRRs characterized in annelids are discussed, and their role in innate defense is suggested.
Permanent Link: http://hdl.handle.net/11104/0318454