Novel targets and strategies to combat borreliosis

0540545 - BC 2021 RIV DE eng J - Journal Article
Strnad, Martin - Grubhoffer, Libor - Rego, Ryan O. M.
Novel targets and strategies to combat borreliosis.
Applied Microbiology and Biotechnology. Roč. 104, č. 5 (2020), s. 1915-1925. ISSN 0175-7598. E-ISSN 1432-0614
R&D Projects: GA ČR(CZ) GA17-21244S
EU Projects: European Commission(XE) 602272 - ANTIDotE
Institutional support: RVO:60077344
Keywords : lyme-disease spirochete * surface-protein-c * decorin binding-protein * ixodes-scapularis * antibiotic-prophylaxis * monoclonal-antibodies * topical azithromycin * oral vaccination * salivary protein * immune-response * Lyme borreliosis * Vaccine candidates * Anti-tick strategies * Human pathogen * Public health
OECD category: Microbiology
Impact factor: 4.813, year: 2020
Method of publishing: Open access
https://link.springer.com/article/10.1007/s00253-020-10375-8

Lyme borreliosis is a bacterial infection that can be spread to humans by infected ticks and may severely affect many organs and tissues. Nearly four decades have elapsed since the discovery of the disease agent called Borrelia burgdorferi. Although there is a plethora of knowledge on the infectious agent and thousands of scientific publications, an effective way on how to combat and prevent Lyme borreliosis has not been found yet. There is no vaccine for humans available, and only one active vaccine program in clinical development is currently running. A spirited search for possible disease interventions is of high public interest as surveillance data indicates that the number of cases of Lyme borreliosis is steadily increasing in Europe and North America. This review provides a condensed digest of the history of vaccine development up to new promising vaccine candidates and strategies that are targeted against Lyme borreliosis, including elements of the tick vector, the reservoir hosts, and the Borrelia pathogen itself.
Permanent Link: http://hdl.handle.net/11104/0318172