Alkoxyalkyl Esters of Nucleotide Analogs Inhibit Polyomavirus DNA Replication and Large T Antigen Activities

0540528 - ÚOCHB 2022 RIV US eng J - Journal Article
Onwubiko, N. O. - Diaz, S. A. - Krečmerová, Marcela - Nasheuer, H. P.
Alkoxyalkyl Esters of Nucleotide Analogs Inhibit Polyomavirus DNA Replication and Large T Antigen Activities.
Antimicrobial Agents and Chemotherapy. Roč. 65, č. 3 (2021), č. článku e01641-20. ISSN 0066-4804. E-ISSN 1098-6596
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : ATPase * DNA helicase * DNA replication * Large T antigen * Nucleoside Analogs * Polyomavirus * Protein-DNA interactions
OECD category: Biochemistry and molecular biology
Impact factor: 5.938, year: 2021
Method of publishing: Limited access
https://doi.org/10.1128/aac.01641-20

Polyomavirus ATPase, DNA helicase, and DNA binding activities of polyomavirus large tumor antigens (Tags) are diminished by low concentrations of alkoxyalkyl-esters of acyclic nucleotide phosphonates (ANPs). Inhibition of viral DNA replication is mediated by inhibiting ssDNA and dsDNA binding activities of Tags. The alkoxyalkyl-esters of ANPs were found effective in vitro without undergoing further conversions.
Permanent Link: http://hdl.handle.net/11104/0318157