Number of the records: 1
Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells
- 1.0540508 - BFÚ 2021 RIV DE eng J - Journal Article
Vašíček, Ondřej - Fedr, Radek - Skoroplyas, Svitlana - Chalupa, D. - Sklenář, M. - Tharra, P. R. - Svenda, J. - Kubala, Lukáš
Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells.
Phytomedicine. Roč. 69, APR 2020 (2020), č. článku 153194. ISSN 0944-7113. E-ISSN 1618-095X
R&D Projects: GA ČR(CZ) GA17-18858S
Institutional support: RVO:68081707
Keywords : pseudeurotium-ovalis stolk * cd40 ligand * ige * proliferation
OECD category: Pharmacology and pharmacy
Impact factor: 5.340, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0944711320300271?via%3Dihub
Background: The frequency of allergic diseases is constantly rising. Dysregulated production of isotype E immunoglobulins is one of the key factors behind allergic reactions and its modulation is therefore an important target for pharmacological intervention. Natural products of the pseurotin family were reported to be inhibitors of IgE production in B-cells. Mechanistic details underlying these effects are however not well understood.
Permanent Link: http://hdl.handle.net/11104/0318133
Number of the records: 1