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The actin regulator profilin 1 is functionally associated with the mammalian centrosome
- 1.0540121 - ÚMG 2023 RIV US eng J - Journal Article
Nejedlá, M. - Klebanovych, Anastasiya - Sulimenko, Vadym - Sulimenko, Tetyana - Dráberová, Eduarda - Dráber, Pavel - Karlsson, R.
The actin regulator profilin 1 is functionally associated with the mammalian centrosome.
Life Science Alliance. Roč. 4, č. 1 (2021), č. článku e202000655. E-ISSN 2575-1077
R&D Projects: GA ČR(CZ) GA18-27197S; GA MŠMT(CZ) LM2018129
Institutional support: RVO:68378050
Keywords : profilin * centrosome * microtubule nucleation
OECD category: Cell biology
Impact factor: 5.781, year: 2021
Method of publishing: Open access
https://www.life-science-alliance.org/content/4/1/e202000655
Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.
Permanent Link: http://hdl.handle.net/11104/0317777
Number of the records: 1