Cell differentiation and aging accompanied by depletion of the ACE2 protein

0540087 - BFÚ 2021 RIV US eng J - Journal Article
Bártová, Eva - Legartová, Soňa - Krejčí, Jana - Arcidiacono, Orazio Angelo
Cell differentiation and aging accompanied by depletion of the ACE2 protein.
Aging. Roč. 12, č. 22 (2020), s. 22495-22508. ISSN 1945-4589
Grant - others:AV ČR(CZ) StrategieAV21/7
Program: StrategieAV
Institutional support: RVO:68081707
Keywords : receptor * regulator * level * ace2 * renin
OECD category: Cell biology
Impact factor: 5.682, year: 2020
Method of publishing: Limited access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746349/

ACE2 was observed as the cell surface receptor of the SARS-CoV-2 virus. Interestingly, we also found ACE2 positivity inside the cell nucleus. The ACE2 levels changed during cell differentiation and aging and varied in distinct cell types. We observed ACE2 depletion in the aortas of aging female mice, similarly, the aging caused ACE2 decrease in the kidneys. Compared with that in the heart, brain and kidneys, the ACE2 level was the lowest in the mouse lungs. In mice exposed to nicotine, ACE2 was not changed in olfactory bulbs but in the lungs, ACE2 was upregulated in females and downregulated in males. These observations indicate the distinct gender-dependent properties of ACE2.
Permanent Link: http://hdl.handle.net/11104/0317751