0539918 - ÚEB 2021 RIV US eng J - Journal Article
Tan, S. - Di Donato, M. - Glanc, M. - Zhang, X. - Klíma, Petr - Liu, J. - Bailly, A. - Ferro, N. - Petrášek, Jan - Geisler, M. - Friml, J.
Non-steroidal Anti-inflammatory Drugs Target TWISTED DWARF1-Regulated Actin Dynamics and Auxin Transport-Mediated Plant Development.
Cell Reports. Roč. 33, č. 9 (2020), č. článku 108463. ISSN 2211-1247. E-ISSN 2211-1247
R&D Projects: GA MŠMT(CZ) EF16_019/0000738
Grant - others:OPPK(XE) CZ.2.16/3.1.00/21519
Institutional support: RVO:61389030
Keywords : actin filament * Arabidopsis * auxin * auxin transport inhibitor * endosomal trafficking * fkbp * non-steroidal anti-inflammatory drug * nsaid * polar auxin transport * twd1
OECD category: Biochemical research methods
Impact factor: 9.423, year: 2020 ; AIS: 4.515, rok: 2020
Method of publishing: Open access
Result website:
http://doi.org/10.1016/j.celrep.2020.108463DOI: https://doi.org/10.1016/j.celrep.2020.108463

The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are derivatives of the phytohormone salicylic acid (SA). SA is well known to regulate plant immunity and development, whereas there have been few reports focusing on the effects of NSAIDs in plants. Our studies here reveal that NSAIDs exhibit largely overlapping physiological activities to SA in the model plant Arabidopsis. NSAID treatments lead to shorter and agravitropic primary roots and inhibited lateral root organogenesis. Notably, in addition to the SA-like action, which in roots involves binding to the protein phosphatase 2A (PP2A), NSAIDs also exhibit PP2A-independent effects. Cell biological and biochemical analyses reveal that many NSAIDs bind directly to and inhibit the chaperone activity of TWISTED DWARF1, thereby regulating actin cytoskeleton dynamics and subsequent endosomal trafficking. Our findings uncover an unexpected bioactivity of human pharmaceuticals in plants and provide insights into the molecular mechanism underlying the cellular action of this class of anti-inflammatory compounds.
Permanent Link: http://hdl.handle.net/11104/0317610