Number of the records: 1
A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs
- 1.0538180 - BC 2021 RIV NL eng J - Journal Article
Sak, Bohumil - Brdíčková, Klára - Holubová, Nikola - Květoňová, Dana - Hlásková, Lenka - Kváč, Martin
A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs.
Microbes and Infection. Roč. 22, č. 9 (2020), s. 467-473. ISSN 1286-4579. E-ISSN 1769-714X
R&D Projects: GA ČR GA17-12871S; GA ČR(CZ) GA20-10706S
Institutional support: RVO:60077344
Keywords : enterocytozoon-bieneusi * microsporidiosis * patient * aids * immunocompetent * identification * intestinalis * albendazole * fumagillin * diversity * Encephalitozoon cuniculi genotype III * Albendazole * CD4(-/-) mice * CD8(-/-) mice * C57Bl/6 mice
OECD category: Epidemiology
Impact factor: 2.700, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1286457920301222?via%3Dihub
Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4(-/-) and CD8(-/-) mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups.
Permanent Link: http://hdl.handle.net/11104/0316003
Number of the records: 1