Cdx2 Animal Models Reveal Developmental Origins of Cancers

0538161 - ÚMG 2021 RIV CH eng J - Journal Article
Chawengsaksophak, Kallayanee
Cdx2 Animal Models Reveal Developmental Origins of Cancers.
Genes. Roč. 10, č. 11 (2019), č. článku 928. E-ISSN 2073-4425
R&D Projects: GA MŠMT LO1419; GA ČR GA17-16959S
Institutional support: RVO:68378050
Keywords : metaplasia * Cdx * cancer * animal models
OECD category: Developmental biology
Impact factor: 3.759, year: 2019
Method of publishing: Open access
https://www.mdpi.com/2073-4425/10/11/928

The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in reassigning positional identity during regeneration can cause metaplasias-normal tissue arising in an abnormal location-and this in turn, is a well-recognized cancer risk factor. In animal models, a gain of Cdx2 function can elicit a posterior shift in tissue identity, modeling intestinal-type metaplasias of the esophagus (Barrett's esophagus) and stomach. Conversely, loss of Cdx2 function can elicit an anterior shift in tissue identity, inducing serrated-type lesions expressing gastric markers in the colon. These metaplasias are major risk factors for the later development of esophageal, stomach and colon cancer. Leukemia, another cancer in which Cdx2 is ectopically expressed, may have mechanistic parallels with epithelial cancers in terms of stress-induced reprogramming. This review will address how animal models have refined our understanding of the role of Cdx2 in these common human cancers.
Permanent Link: http://hdl.handle.net/11104/0315982