Sex Differences in Heart Disease

0537904 - FGÚ 2021 RIV CH eng M - Monography Chapter
Ošťádal, Bohuslav - Ošťádal, P. - Neckář, Jan
Sex Differences in Cardiac Ischemia/Reperfusion Injury.
Sex Differences in Heart Disease. Cham: Springer International Publishing, 2020 - (Dhalla, N.; Ošťádal, B.), s. 25-37. Advances in Biochemistry in Health and Disease, 21. ISBN 978-3-030-58676-8
R&D Projects: GA ČR(CZ) GA18-03207S
Institutional support: RVO:67985823
Keywords : sex differences * ischemia/reperfusion injury * role of estrogen * cardiac tolarance
OECD category: Physiology (including cytology)
https://doi.org/10.1007/978-3-030-58677-5_2

I tis now well known that differences in the structure and function of the heart exist between male and female hearts. Several lines of exerimental and clinical investigations have reported that there are sex differences in the tolerance to myocardial ischemia, whereby adult male hearts are more susceptible to ischemia/reperfusion (I/R) injury as compared to pre-menopausal female hearts. Experimental studies have also shown that adult female hearts have increased resistence and male hearts are more susceptible to I/R in animal exposed to perinatal hypoxia. Although there is now a large body of evidence which indicates that estrogen is involved in the sex differences with respect to cardiac tolerance to ischemia, the exact mechanisms involved in the cardiac response to ischemia or hypoxia are not fully understood. Accordingly, this chapter is intended to describe some of the known molecular nad cellular mechanisms that contribute to sex differences in the susceptibility to I/R injury. With such a new basic information and advancements in the understanding of the mechanisms responsible for sex differences in cardiac sensitivity to ischemic injury, it is hoped that some specific therapeutic strategies will be developed for post-menopausal females for better quality of life, and lower mortality.
Permanent Link: http://hdl.handle.net/11104/0315741