.sup.1./sup.H, .sup.13./sup.C and .sup.15./sup.N NMR of spiro acridines integrated with pyrrole scaffolds

0537827 - FZÚ 2021 RIV US eng J - Journal Article
Vilková, M. - Šoral, M. - Bečka, M. - Potočňák, I. - Sabolová, D. - Béres, T. - Dušek, Michal - Imrich, J.
¹H, ¹³C and ¹⁵N NMR of spiro acridines integrated with pyrrole scaffolds.
Magnetic Resonance in Chemistry. Roč. 58, č. 2 (2020), s. 204-214. ISSN 0749-1581. E-ISSN 1097-458X
R&D Projects: GA MŠMT(CZ) LO1603
EU Projects: European Commission(CZ) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : acridines * pyrrole scaffolds * antiviral * antibacterial * X-ray crystallography * crystal structure
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.447, year: 2020
Method of publishing: Limited access
https://doi.org/10.1002/mrc.4974

Acridines are important organic compounds with potent biological properties, which are in focus of our longterm research. The hydrazide–hydrazone fragment CH=N-NH-CO represents a significant structural unit with a wide range of biological activities such as antitumor, antimicrobial, anti‐inflammatory, and antituberculotic. The use of acridine derivatives in the synthesis of hydrazide–hydrazones has seemed favorable to us because of their interesting antiviral, antibacterial, and antitumor properties. In connection with our ongoing studies on the new acridine derivatives, we decided to prepare compounds containing both hydrazide–hydrazone and acridine substructures for utilization in the synthesis of heterocycles.

Permanent Link: http://hdl.handle.net/11104/0315662