Synthesis, characterization and in vitro evaluation of anticancer activity of a new water-soluble thiosemicarbazone ligand and its complexes

0537815 - FZÚ 2021 RIV GB eng J - Journal Article
Sardroud, S.J. - Hosseini-Yazdi, S.A. - Mahdavi, M. - Poupon, Morgane - Skořepová, Eliška
Synthesis, characterization and in vitro evaluation of anticancer activity of a new water-soluble thiosemicarbazone ligand and its complexes.
Polyhedron. Roč. 175, Jan (2020), s. 1-10, č. článku 114218. ISSN 0277-5387. E-ISSN 1873-3719
R&D Projects: GA MŠMT(CZ) LO1603; GA ČR(CZ) GA18-10504S
EU Projects: European Commission(CZ) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : apoptosis * cell cycle * cytotoxicity * flow cytometry * Schiff base * thiosemicarbazone
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.052, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.poly.2019.114218

A new water-soluble thiosemicarbazone ligand, 4-hydroxyl-3-({[(methylamino)carbonothioyl] hydrazono}methyl)benzoic acid (H3LCOOH) and its complexes with Cu(II), Ni(II), Zn(II), Fe(III) and Mn(III) were synthesized and characterized. These compounds were characterized by conductivity, magnetic susceptibility, elemental analysis, FT-IR, 1H NMR, 13C NMR, and UV–Vis spectroscopy. All the complexes significantly showed more anticancer activity than the ligand alone and the Cu(II) complex showed considerable cytotoxicity against the tested cell lines.
Permanent Link: http://hdl.handle.net/11104/0315650