Synthesis, characterization and cytotoxic activity of binuclear copper(II)-complexes with some S-isoalkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-isopropyl derivative of thiosalicylic acid

0537756 - FZÚ 2021 RIV US eng J - Journal Article
Dimitrijevic, J. - Arsenijevic, A.N. - Milovanovic, M.Z. - Arsenijevic, N.N. - Milovanovic, J.Z. - Stankovic, A.S. - Bukonjic, A.M. - Tomovic, D.L. - Ratkovic, Z.R. - Potočňák, I. - Samoľová, Erika - Radic, G.P.
Synthesis, characterization and cytotoxic activity of binuclear copper(II)-complexes with some S-isoalkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-isopropyl derivative of thiosalicylic acid.
Journal of Inorganic Biochemistry. Roč. 208, July (2020), s. 1-11, č. článku 111078. ISSN 0162-0134. E-ISSN 1873-3344
R&D Projects: GA MŠMT(CZ) LO1603
EU Projects: European Commission(CZ) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : S,O-ligands * copper(II)-complexes * crystal structure * biological activity
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 4.155, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.jinorgbio.2020.111078

Isoalkyl (isoalkyl= isopropyl-(L1), isobutyl-(L2) and isoamyl-(L3)) derivatives of thiosalicylic acid (TSA) were pre-pared by alkylation of TSA with corresponding isoalkyl-chlorides in the alkaline water-ethanol solution. The new freecopper(II)-complexes with corresponding S-isoalkyl derivatives of TSA have been synthesized by direct reaction of copper(II)-nitratewith ligand precursor and then characterized by microanalysis, infrared spectra and EPR spectra. The spectroscopically predicted structure of the obtained binuclear copper(II)-complex with S-isopropyl derivative of thiosalicylic acid was confirmed by X-ray analysis. Single crystals suitable for X-ray measure-ments were obtained by slow crystallization from a water solution. All new complexes exhibited apoptotic effect toward lung cancer cells,stronger than cisplatin, whereas only C3 induced significant apoptosis of colorectal cancer cells.

Permanent Link: http://hdl.handle.net/11104/0315599