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Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications

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    0537561 - FZÚ 2021 RIV NL eng J - Journal Article
    Frtús, Adam - Smolková, Barbora - Uzhytchak, Mariia - Lunova, Mariia - Jirsa, M. - Kubinová, Šárka - Dejneka, Alexandr - Lunov, Oleg
    Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications.
    Journal of Controlled Release. Roč. 328, Dec (2020), s. 59-77. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA MŠk LTC19040
    Institutional support: RVO:68378271
    Keywords : iron oxide nanoparticles * endocytosis * magnetic resonance imaging * cytotoxicity * lysosomes * apoptosis * autophagy * cancer
    OECD category: Biophysics
    Impact factor: 9.776, year: 2020
    Method of publishing: Limited access
    https://doi.org/10.1016/j.jconrel.2020.08.036

    Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification.
    Permanent Link: http://hdl.handle.net/11104/0315381

     
     
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