Multifunctional Fe.sub.3./sub.O.sub.4./sub.-Au nanoparticles for the MRI diagnosis and potential treatment of liver cancer

0537368 - FZÚ 2021 RIV CH eng J - Journal Article
Kozenkova, E. - Levada, K. - Efremova, M.V. - Omelyanchik, A. - Nalench, Y.A. - Garanina, A.S. - Pshenichnikov, S. - Zhukov, D.G. - Lunov, Oleg - Lunova, M. - Kozenkov, I. - Innocenti, C. - Albino, M. - Abakumov, M.A. - Sangregorio, C. - Rodionova, V.
Multifunctional Fe₃O₄-Au nanoparticles for the MRI diagnosis and potential treatment of liver cancer.
Nanomaterials. Roč. 10, č. 9 (2020), s. 1-15, č. článku 1646. E-ISSN 2079-4991
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : magnetic-plasmonic nanoparticles * nano-heterostructures * MRI contrast agent * liver cancer * theranostic
OECD category: Biophysics
Impact factor: 5.076, year: 2020
Method of publishing: Open access

In this work, Fe3O4-Au nano-heterostructures were synthesized by a one-step thermal decomposition method. The hybrid nanoparticles comprise a highly crystalline 12 nm magnetite octahedron decorated with a single noble metal sphere of 6 nm diameter. The cytotoxic effect of the nanoparticles in the human hepatic cell line Huh7 and PLC/PRF/5-Alexander was also assessed. These Fe3O4-Au bifunctional nanoparticles showed no significant cytotoxicity in these two cell lines. The nanoparticles showed a good theranostic potential for liver cancer treatment, since the r2 relaxivity (166.5 mM−1·s−1 and 99.5 mM−1·s−1 in water and HepG2 cells, respectively) is higher than the corresponding values for commercial T2 contrast agents and the Specific Absorption Rate (SAR) value obtained (227 W/gFe) is enough to make them suitable as heat mediators for Magnetic Fluid Hyperthermia. The gold counterpart can further allow the conjugation with different biomolecules and the optical sensing.

Permanent Link: http://hdl.handle.net/11104/0315084