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Mild and Selective Method of Bromination of Flavonoids
- 1.0537121 - MBÚ 2021 RIV US eng J - Journal Article
Hurtová, Martina - Biedermann, David - Kuzma, Marek - Křen, Vladimír
Mild and Selective Method of Bromination of Flavonoids.
Journal of Natural Products. Roč. 83, č. 11 (2020), s. 3324-3331. ISSN 0163-3864. E-ISSN 1520-6025
R&D Projects: GA ČR(CZ) GA18-00150S; GA MŠMT(CZ) LTC20070
Institutional support: RVO:61388971
Keywords : Silybin * Flavonolignans * Silicristin
OECD category: Organic chemistry
Impact factor: 4.050, year: 2020
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00655
A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.
Permanent Link: http://hdl.handle.net/11104/0314868
Number of the records: 1