Understanding Gas Phase Ion Chemistry Is the Key to Reliable Selected Ion Flow Tube-Mass Spectrometry Analyses

0537005 - ÚFCH JH 2021 RIV US eng J - Journal Article
Smith, D. - McEwan, M. J. - Španěl, Patrik
Understanding Gas Phase Ion Chemistry Is the Key to Reliable Selected Ion Flow Tube-Mass Spectrometry Analyses.
Analytical Chemistry. Roč. 92, č. 19 (2020), s. 12750-12762. ISSN 0003-2700. E-ISSN 1520-6882
Institutional support: RVO:61388955
Keywords : ptr-tof-ms * sift-ms * humid air * organic-compounds * exhaled breath * o-2(+) ions * no+ * h3o+ * quantification * series
OECD category: Physical chemistry
Impact factor: 6.986, year: 2020
Method of publishing: Limited access

Ion-molecule reactions (IMR) are at the very core of trace gas analyses in modern chemical ionization (CI) mass spectrometer instruments, which are increasingly being used in diverse areas of research and industry. The focus of this Perspective is on the ion chemistry that underpins gas-phase analytical CI methods. Special attention is given to the soft chemical ionization method known as selected ion flow tube-mass spectrometry (SIFT-MS). The processes involved in the ion chemistry of the reagent cations, H3O+, NO+, and O-2(+center dot), and the anions, O-center dot, O-2(-center dot), OH-, and NO2-, are discussed in some detail. Stressed throughout is that an understanding of these processes is mandatory to obtain reliable analyses of humid gaseous media such as ambient air and exhaled breath. It is indicated that further research is needed to understand the consequences of replacing helium in some situations by the more readily available nitrogen as the carrier gas in SIFT-MS.
Permanent Link: http://hdl.handle.net/11104/0314768