Translational Research in Serious Human Diseases

0536622 - ÚŽFG 2021 RIV CZ eng M - Monography Chapter
Ďuríček, Tomáš - Šolc, Petr
Micronucleus as a mark of genome integrity problems.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 224-231. ISBN 978-80-200-3158-7
R&D Projects: GA MŠMT(CZ) LO1609
Institutional support: RVO:67985904
Keywords : micronucleus * DNA damage * DNA damage checkpoints
OECD category: Cell biology

Micronucleus (MN) is a small round and DNA containing structure located in the cytoplasm outside of the main nucleus. The presence of MN is considered as a sign of chromosomal instability. MN contains a part of an entire chromosome that was incorrectly segregated during anaphase and fail to incorporate into the daughter's cell nuclei correctly. Replication stress, un-replicated DNA, mitotic spindle defects, DNA damage, and non-functional DNA damage checkpoints are contributing to MN formation. Since zygote is a fundament of a whole new organism, the presence of MN in this cell can cause embryonal mortality, infertility or serious congenital disorders.
Permanent Link: http://hdl.handle.net/11104/0314369