Translational Research in Serious Human Diseases

0536530 - ÚŽFG 2021 RIV CZ eng M - Monography Chapter
Novák, Jaromír - Kupcová Skalníková, Helena
Extracellular vesicles: a potential source of biomarkers in neurodegenerative diseases.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 123-131. ISBN 978-80-200-3158-7
R&D Projects: GA MŠMT(CZ) LO1609; GA ČR(CZ) GA19-01747S
Institutional support: RVO:67985904
Keywords : extracellular vesicles * exosomes * body fluids
OECD category: Biochemistry and molecular biology

Extracellular vesicles (EVs) are mediators of intercellular communication, which can transfer protein, RNA or small molecules into recipient cells and change their phenotype. In the central nervous system, EVs play roles in various physiological functions, including development, synaptic transmission or neuronal protection and regeneration. In neurodegenerative diseases, EVs may participate in transfer of misfolded proteins into healthy cells but possess also diagnostic/prognostic and therapeutic potential. Research of neurodegenerative disease pathophysiology is limited to studies on cellular models, experimental animals or post-mortem tissues. EVs offer a valuable alternative to access the diseased nervous system with minimal invasiveness.
Permanent Link: http://hdl.handle.net/11104/0314302