0536497 - ÚŽFG 2021 RIV CZ eng M - Monography Chapter
Sekáč, David
Presence of oxidative stress in Huntington´s disease pathogenesis.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 43-48. ISBN 978-80-200-3158-7
R&D Projects: GA MŠMT(CZ) LO1609
Institutional support: RVO:67985904
Keywords : reactive molecules * antioxidants * mutant huntingtin
OECD category: Cell biology

Huntingtin protein (HTT) participates in many molecular processes, which are disrupted by its mutation. Also, mutated huntingtin (mHTT) may gain new functions that are toxic to the cell. An example is the impairment of mitochondria function and the associated redox state. Since mitochondria are a major source of superoxide radicals, their dysfunction leads to energy deficit and oxidative stress. This state exhausts the antioxidant defence, resulting in impairment of cellular integrity and apoptosis.
Permanent Link: http://hdl.handle.net/11104/0314270