Copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide, polymer brushes

0536426 - ÚMCH 2021 RIV eng P - Patent Document
Rodriguez-Emmenegger, Cesar - Surman, František - Brynda, Eduard - Riedel, Tomáš - Houska, Milan - Lísalová, Hana - Homola, Jiří
Copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide, polymer brushes.
2020. Owner: Ústav makromolekulární chemie AV ČR, v. v. i. - Ústav fotoniky a elektroniky AV ČR, v. v. i. Date of the patent acceptance: 08.04.2020. Patent Number: EP3292161
R&D Projects: GA ČR(CZ) GBP205/12/G118
Institutional support: RVO:61389013 ; RVO:67985882
Keywords : antifouling copolymer brushes * bioactive functionalization * biosensors
OECD category: Polymer science; Optics (including laser optics and quantum optics) (URE-Y)
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20200408&DB=&locale=en_EP&CC=EP&NR=3292161B1&KC=B1&ND=4#

The present invention relates to the preparation and use of copolymers composed of N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxybetaine methacrylamide (CBMAA). The invention further describes polymer brushes having structure I S--R-polymer (I) wherein S is a substrate, R is a residue of a polymerization initiator or a RAFT agent bound to the substrate, and “polymer” is the copolymer of N-(2-hydroxypropyl) methacrylamide and carboxybetaine methacrylamide. Furthermore, production of these polymer brushes, containing random or block copolymers grafted to or from a substrate is described. The copolymer brushes are suitable for protecting substrates from deposition and/or adhesion of biological substances, and/or against thrombus formation. The brushes functionalized by covalent attachment of bioactive substances to CBMAA monomer units are particularly suitable for specific interaction with target biological substances which is not affected by nonspecific deposition of non-target compounds.
Permanent Link: http://hdl.handle.net/11104/0315857