Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

0536338 - ÚVGZ 2021 RIV US eng J - Journal Article
Malaník, M. - Treml, J. - Leláková, V. - Nykodymová, D. - Oravec, Michal - Marek, J. - Smejkal, K.
Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera.
Bioorganic Chemistry. Roč. 104, NOV (2020), č. článku 104298. ISSN 0045-2068. E-ISSN 1090-2120
R&D Projects: GA MŠMT(CZ) EF16_019/0000797
Institutional support: RVO:86652079
Keywords : cultivated mulberry tree * 1,3-diphenylpropane derivatives * in-vitro * flavonoids * components * bark * Broussonetia papyrifera * Anti-inflammatory * Antioxidant * NF-kappa B
OECD category: Biochemistry and molecular biology
Impact factor: 5.275, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub

Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
Permanent Link: http://hdl.handle.net/11104/0314122