Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm

0535623 - ÚPT 2021 RIV AT eng J - Journal Article
Bočková, M. - Lamoš, M. - Klimeš, Petr - Jurák, Pavel - Halámek, Josef - Goldemundová, S. - Baláž, M. - Rektor, I.
Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm.
Journal of Neural Transmission. Roč. 127, č. 12 (2020), s. 1579-1588. ISSN 0300-9564. E-ISSN 1435-1463
R&D Projects: GA MZd(CZ) NV16-33798A
Institutional support: RVO:68081731
Keywords : HD-EEG * deep brain stimulation * reaction time * time frequency analysis * biomarkers
OECD category: Medical engineering
Impact factor: 3.575, year: 2020
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00702-020-02254-3

Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS off and on conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS on state than in the DBS off state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS on condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.
Permanent Link: http://hdl.handle.net/11104/0313587