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Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot

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    0535240 - FGÚ 2021 RIV US eng J - Journal Article
    Novotný, Tomáš - Eckhardt, Adam - Knitlová, Jarmila - Doubková, Martina - Ošťádal, M. - Uhlík, J. - Musílková, Jana
    Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot.
    Journal of Pediatric Orthopaedics. Roč. 40, č. 10 (2020), s. 592-596. ISSN 0271-6798. E-ISSN 1539-2570
    R&D Projects: GA MZd(CZ) NV17-31564A
    Institutional support: RVO:67985823
    Keywords : clubfoot * microvessel density * arteriole density * proangiogenic factors * gene expression * immunohistochemistry
    Subject RIV: FI - Traumatology, Orthopedics
    OBOR OECD: Orthopaedics
    Impact factor: 2.324, year: 2020
    https://journals.lww.com/pedorthopaedics/Abstract/2020/11000/Increased_Microvessel_and_Arteriole_Density_in_the.17.aspx

    Clubfoot deformity (pes equinovarus) is one of the most common birth defects, and its etiology is still unknown. Initial clubfoot treatment is based on the Ponseti method throughout most of the world. Despite the effectiveness of this therapy, clubfoot may relapse. Recent studies confirm the theory of active fibrotic remodeling processes in the extracellular matrix of the affected tissue. The aim of this study was to clarify whether relapses in clubfoot therapy are associated with altered angiogenesis and to suggest possible regulatory pathways of this pathologic process.
    Permanent Link: http://hdl.handle.net/11104/0313326
     
Number of the records: 1