Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot

0535240 - FGÚ 2021 RIV US eng J - Journal Article
Novotný, Tomáš - Eckhardt, Adam - Knitlová, Jarmila - Doubková, Martina - Ošťádal, M. - Uhlík, J. - Musílková, Jana
Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot.
Journal of Pediatric Orthopaedics. Roč. 40, č. 10 (2020), s. 592-596. ISSN 0271-6798. E-ISSN 1539-2570
R&D Projects: GA MZd(CZ) NV17-31564A
Institutional support: RVO:67985823
Keywords : clubfoot * microvessel density * arteriole density * proangiogenic factors * gene expression * immunohistochemistry
OECD category: Orthopaedics
Impact factor: 2.324, year: 2020
Method of publishing: Limited access
https://journals.lww.com/pedorthopaedics/Abstract/2020/11000/Increased_Microvessel_and_Arteriole_Density_in_the.17.aspx

Clubfoot deformity (pes equinovarus) is one of the most common birth defects, and its etiology is still unknown. Initial clubfoot treatment is based on the Ponseti method throughout most of the world. Despite the effectiveness of this therapy, clubfoot may relapse. Recent studies confirm the theory of active fibrotic remodeling processes in the extracellular matrix of the affected tissue. The aim of this study was to clarify whether relapses in clubfoot therapy are associated with altered angiogenesis and to suggest possible regulatory pathways of this pathologic process.
Permanent Link: http://hdl.handle.net/11104/0313326