Mechanical and structural properties of collagen nanofribrous layers under simulated body conditions

0534515 - ÚSMH 2021 RIV CZ eng C - Conference Paper (international conference)
Říhová, J. - Suchý, Tomáš - Vištejnová, L. - Horný, L. - Šupová, Monika
Mechanical and structural properties of collagen nanofribrous layers under simulated body conditions.
Acta Polytechnica CTU Proceedings. Vol. 25. Praha: Czech Technical University in Prague, 2019 - (Kytýř, D.; Zlámal, P.; Doktor, T.), s. 73-78. ISBN 978-80-01-06670-6.
[Youth Symposium on Experimental Solid Mechanics /17./. Telč (CZ), 06.06.2019-08.06.2019]
Institutional support: RVO:67985891
Keywords : collagen * fibroblasts * osteoblasts * mechanical properties * structural properties * biodegradation
OECD category: Applied mechanics
https://ojs.cvut.cz/ojs/index.php/APP/article/view/6031/5306

The theme of this paper is the analysis of mechanical and structural properties of nanofibrous COL under simulated body conditions and in the presence of osteoblasts and dermal fibroblasts. COL were prepared by electrostatic spinning of 8 wt% collagen type I dispersion with 8 wt% (to COL) of PEG in phosphate buffer/ethanol solution (1/1 vol). The stability of COL was enhanced by means of cross-linking with EDC and NHS at a molar ratio of 4:1. COL were exposed in culture medium for 21 days and human SAOS-2 human dermal fibroblasts and osteoblasts were cultured therein for 21 days as well.
Permanent Link: http://hdl.handle.net/11104/0313345