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Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer

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    0534443 - ÚMCH 2021 RIV CH eng J - Journal Article
    Babuka, David - Kolouchová, Kristýna - Groborz, Ondřej - Tosner, Z. - Zhigunov, Alexander - Štěpánek, Petr - Hrubý, Martin
    Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer.
    Nanomaterials. Roč. 10, č. 11 (2020), s. 1-17, č. článku 2231. ISSN 2079-4991
    R&D Projects: GA MŠk(CZ) LTC19032; GA ČR(CZ) GA19-01602S; GA ČR(CZ) GA18-07983S
    EU Projects: European Commission(XE) 686089 - PRECIOUS
    Institutional support: RVO:61389013
    Keywords : fluorine-19 * magnetic resonance imaging * self-assembly
    Subject RIV: CD - Macromolecular Chemistry
    OBOR OECD: Polymer science
    Impact factor: 4.324, year: 2019
    https://www.mdpi.com/2079-4991/10/11/2231

    Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei.
    Permanent Link: http://hdl.handle.net/11104/0312876
     
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