The synthesis, characterization, DNA/BSA/HSA interactions, molecular modeling, antibacterial properties, andin vitrocytotoxic activities of novel parent and niosome nano-encapsulated Ho(iii) complexes

0533712 - FZÚ 2021 RIV GB eng J - Journal Article
Deng, Y. - Foroughi, M.M. - Aramesh-Boroujeni, Z. - Jahani, S. - Peydayesh, M. - Borhani, F. - Khatami, M. - Rohani, M. - Dušek, Michal - Eigner, Václav
The synthesis, characterization, DNA/BSA/HSA interactions, molecular modeling, antibacterial properties, andin vitrocytotoxic activities of novel parent and niosome nano-encapsulated Ho(iii) complexes.
RSC Advances. Roč. 10, č. 39 (2020), s. 22891-22908. E-ISSN 2046-2069
R&D Projects: GA MŠMT(CZ) LO1603; GA ČR(CZ) GA18-10504S
EU Projects: European Commission(CZ) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : metal centered complexes * antibacterial properties * crystal structure * FT-IR * X-ray diffraction
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.361, year: 2020
Method of publishing: Open access
https://doi.org/10.1039/d0ra03436c

Based on the importance of metal-centered complexes that can interact with DNA, this research focused on the synthesis of a new Ho(III) complex. This complex was isolated and characterized via elemental analysis, and FT-IR, fluorescence, and UV-vis spectroscopy. Additional confirmation of the Ho(III) complex structure was obtained via single-crystal X-ray diffraction. DNA interaction studies were carried out via circular dichroism (CD) spectroscopy, UV-vis absorption spectroscopy, viscosity measurements and emission spectroscopy. Also, the interactions of this complex with human (HSA) and bovine serum albumin (BSA) proteins were studied via fluorescence spectroscopy techniques and the obtained results reveal an excellent propensity for binding in both cases.
Permanent Link: http://hdl.handle.net/11104/0312016