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Radiolabeled hormones in insulin research, a minireview
- 1.0533542 - ÚOCHB 2021 RIV GB eng J - Journal Article
Jiráček, Jiří - Žáková, Lenka - Marek, Aleš
Radiolabeled hormones in insulin research, a minireview.
Journal of Labelled Compounds and Radiopharmaceuticals. Roč. 63, č. 14 (2020), s. 576-581. ISSN 0362-4803. E-ISSN 1099-1344
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA19-14069S
Institutional support: RVO:61388963
Keywords : assay * binding * hormone * IGF * insulin * radiolabeling * receptor
OECD category: Biochemistry and molecular biology
Impact factor: 1.921, year: 2020
Method of publishing: Limited access
https://doi.org/10.1002/jlcr.3881
This minireview briefly summarizes a history of insulin research employing iodinated insulin-like hormones. Preparation of both 125I-labeled insulin and insulin-like growth factor 1 (IGF-1) was critical because it enabled a detailed characterization of binding properties of these important hormones towards their cognate transmembrane receptors. Binding modes of hundreds of hormone derivatives were analyzed using competition radioligand binding assays. This effort has resulted in development of six insulin analogs that are today clinically used for the treatment of diabetes.
Permanent Link: http://hdl.handle.net/11104/0312368
Number of the records: 1