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The neglected part of early embryonic development: maternal protein degradation
- 1.0533419 - ÚŽFG 2021 RIV CH eng J - Journal Article
Toralová, Tereza - Kinterová, Veronika - Chmelíková, E. - Kaňka, Jiří
The neglected part of early embryonic development: maternal protein degradation.
Cellular and Molecular Life Sciences. Roč. 77, č. 16 (2020), s. 3177-3194. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR GP13-24730P
Institutional support: RVO:67985904
Keywords : ubiquitin * proteasome system * maternal to zygotic transition
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 9.261, year: 2020
Method of publishing: Limited access
https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=21109528615
The degradation of maternally provided molecules is a very important process during early embryogenesis. However, the vast majority of studies deals with mRNA degradation and protein degradation is only a very little explored process yet. The aim of this article was to summarize current knowledge about the protein degradation during embryogenesis of mammals. In addition to resuming of known data concerning mammalian embryogenesis, we tried to fill the gaps in knowledge by comparison with facts known about protein degradation in early embryos of non-mammalian species. Maternal protein degradation seems to be driven by very strict rules in terms of specificity and timing. The degradation of some maternal proteins is certainly necessary for the normal course of embryonic genome activation (EGA) and several concrete proteins that need to be degraded before major EGA have been already found. Nevertheless, the most important period seems to take place even before preimplantation development-during oocyte maturation. The defects arisen during this period seems to be later irreparable.
Permanent Link: http://hdl.handle.net/11104/0311806
Number of the records: 1