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The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels
- 1.0533335 - ÚOCHB 2021 RIV GB eng J - Journal Article
Dzianová, P. - Asai, Seiya - Chrudinová, Martina - Kosinová, L. - Potalitsyn, Pavlo - Šácha, Pavel - Hadravová, Romana - Selicharová, Irena - Kříž, J. - Turkenburg, J. P. - Brzozowski, A. M. - Jiráček, Jiří - Žáková, Lenka
The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels.
Open Biology. Roč. 10, č. 10 (2020), č. článku 200137. E-ISSN 2046-2441
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin * zinc * beta cells * production ZnT8
OECD category: Biochemistry and molecular biology
Impact factor: 6.411, year: 2020
Method of publishing: Open access
https://doi.org/10.1098/rsob.200137
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However,the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. We showed that the disruption of zinc homeostasis in the model β-cells correlated with their impaired insulin and ZnT8 production. This indicates a need for in-depth fundamental research about the role of zinc in insulin production and storage.
Permanent Link: http://hdl.handle.net/11104/0311840
Number of the records: 1